Brochure SFC/SFE

Advantages of Circular Dichroism (CD) Detection in preparative SFC

Separation of Chiral Compunds by High-Throughput Supercritical Fluid Chromatography (HT-SFC)

The JASCO HT-SFC system achieves high-throughput chromatographic analysis employing the AS-2059-SF Autosampler and automated column selection switching valve. It allows faster method development of multiple samples compared with normal HPLC or SFC. By using the CD-2095 Circular Dichroism detector and a chiral separation column, chiral compounds can be analyzed in a short period of time. Supercritical mobile phase offers a low pressure drop across the column so that a high flow rate can be applied, enabling shorter analysis time without sacrificing resolution

Schematic FLow Diagram of the System

1.Liquid carbon dioxide cylinder
2.Modifier
3.PU-2080-CO2 CO2 delivery pump
4.PU-2080 delivery pump for modifier
5.Solvent selector valve
6.Stop valve
7.Safty valve
8.Mixer
9.Accumulator
10.AS-2059-SF autosampler
11.HV-2080-03 column selector valve
12.Chiral column
13.CO-2060 column oven
14.MD-2015 diode array detector with high pressure flow cell
15.CD-2095 circular dichroism detector with high pressure flow cell
16.BP-2080 automatic back pressure regulator

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