Brochure SFC/SFE

Advantages of Circular Dichroism (CD) Detection in preparative SFC


Introducing Jasco's New Preparative SFE/SFC System with Chiral Detection




JASCO is proud to announce the release of our new Preparative SFE/SFC system. This unit features a versatile modular design and excellent performance.

The heart of the system is JASCO'S patented award-winning back- pressure regulator which allows control of system pressure regardless of solvent composition and flowrate. The pumping system is based on the proven performance of our 1500 series analytical SFE/SFC system and can deliver up to 120ml/min of CO2 and 60 ml/min of modifier and flush solvents at pressures up to 35 MPa (5000 psi). Injections can be manual or fully automated. Repetitive injections can be performed to overlay chromatographic runs. Detection choices include UV and/or CD with MS interface capability.

Fraction collection of up to 8 fractions by time, signal level and/or slope is standard. In addition, spectral purity monitoring of Chiral molecules using the g-factor output of the CD detector is standard with the CD detector option.

Up to 20 mm x 250 mm columns can be accommodated in the column oven while 30mm and larger columns can be used outside the oven.

SFCNav Process control software is designed for fully automated operation, monitoring and recording of chromatograms, temperatures, and pressures.
CD-2095 Circular diïchroism detector JASCO SFC-NAV

 

• Chiral Supercritical Fluid Chromatography (SFC) with CO2 potentially offers a shorter analysis time due to higher diffusivity and lower viscosity and reduction of the amount of organic solvents.

• A circular dichroism (CD) detector can effectively be used for determination of chiral purity of chromatographic peaks. G- factor that is defined as CD/UV or ? AU/AU, is a value independent of the chromatographic peak concentration.

Using a CD detector, the g-factor precisely tells the timing when to start/stop fractionation, resulting in high-purity fractions .

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